In 1941 by now an accomplished pianist, Eddie travels to Chicago in the hope of finding some new musical opportunities. He also expects to discover a less racist atmosphere than there is in the South.
After some years working alongside Sonny Boy Williamson II on stage, Eddie joins him for a recording session in 1945, at which 'Elevator Woman' and Sonny Boy's Jump' are cut.
Lester Melrose, who had signed Eddie to Victor, arranges for him to play piano at a session with Big Maceo in 1947. Ace pianist Maceo had suffered paralysis to his right hand side.
Having been billed by Melrose as 'Little Eddie Boyd', he attends the last of his five recording sessions for Victor in 1949.
He records for the JOB label and then for Chess in 1951. Leonard Chess tells him he is talentless and that the material will be used to better advantage by Eddie's cousin Muddy Waters.
Eddie achieves great success in 1952, with 'Five Long Years' and '24 Hours' after recording and releasing them using his own money, the following year 'Third Degree' becomes his third sizeable hit within a twelve month span.
In 1957 a car crash in Illinois results in Eddie being laid up injured for three months at a time when his popularity is in decline.
After having been part of the American Folk Blues Festival in 1965, Eddie decides to settle in Europe.
He records 7936 South Rhodes, backed by Fleetwood Mac in 1968.
After having lived in France, Belgium, Holland, Switzerland and Denmark, Eddie marries a Finnish national in 1970 and settles in her native land.
He undergoes heart surgery for replacement of a defective valve in 1980.
He receives a warm response at the 1986 Chicago Blues Festival.
He releases a cassette of religious music in 1993.
Eddie Boyd dies in Meilahti Hospital, Helsinki, on 13 July 1994.